According to Prof. Gefen so far were performed fireplace screens using the algorithm two experiment

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Cell imaging. Photo: Prof. Amit Gefen, Tel Aviv University, Tel Aviv University researchers have developed a computer model of load cells endurance trials examining fireplace screens tissue mechanical loads in the context of chronic wounds, such as pressure sores. The development will save the lives of animals and allows the improvement of the clinical trials.
One of the practical and ethical problems facing scientific research is needed, which in many cases is inevitable, fireplace screens animal experimentation. Now at least one area of study may be waived in favor of animal experiments combining tissue culture experiments and computer software.
Prof. Amit Gefen Department of Biomedical Engineering at the Faculty of Engineering Iby and Aladar Fleischman Tel Aviv University has developed a computer algorithm, when the three-dimensional scanners into living cells using laser microscope fireplace screens Konfokeli, is able to continue to make the computer model of the many causes cell experiments cell deformation and see how it behaves.
Gefen discusses a recent study of chronic wounds, particularly bed sores and ulcers in the feet of diabetic patients which is the first cause of amputation of the legs. Bedsores, Contrary to conventional appear not only in the elderly but for all who suffer from motor or sensory, ranging from premature babies through road accident victims who became paralyzed, fireplace screens strokes and even healthy people who entered fireplace screens a long analysis developed fireplace screens bedsores. To investigate this issue and learn how to create fireplace screens bedsores fireplace screens and how it evolves required Gefen initially experimenting unpleasant, especially rats, involved in causing wounds to live (anesthesia) and who had problems such as the difficulty back accurate test to confirm the result.
In recent years moved Gefen instead use tissue cultures - skin cells, muscle, bone and cell required issued once the bodies of animals (and in some cases of humans, skin, for example), and since then they have multiplied in the laboratory, and every time you can take advantage of them re-trials.
The next step, after the physical test laboratory is to continue to perform fireplace screens many experiments on the same cell to examine fireplace screens the behavior and not to destroy the cell. These experiments give it to your computer, fireplace screens or rather scanners him, and give a computerized algorithm to continue to "abuse" in the cell, changing environmental conditions, exert pressure and to examine the behavior of the cell, as in any scientific experiment, including rehearsals under controlled conditions.
They present the method developed - the modeling of cell finite element method (Finite Element Analysis), a technique for calculating the differential equations numerically. First scan the cell using a laser microscope fireplace screens Konfokeli and then run the algorithm and computer scanned for specific cell how he might react in different conditions the forces exerted on it. The method was developed as part of a doctoral thesis Noa Slumka, supervised by Prof. Gefen.
According to Prof. Gefen, this is a new direction mechanics fireplace screens of cells, which allows quantification of distortion, tension and pressure in and around the cell, as well as the identification of mechanical properties of cells and organelles within fireplace screens the cell same experiment scanners from cell cultures.
"Recently there have been attempts to develop models for two-dimensional and three-dimensional cell, using geometry ideal of cells or imaging of cells are real, but the three-dimensional modeling based microscopy of specific cells, which will allow analysis of distortion on a large scale, was not developed until now. Our goal modeling method was developed to provide a three-dimensional representation Rilsti of cells, including the sub-cell components such as cell nuclei, intracellular fluid (Cytosol), the cell's fireplace screens plasma membrane and cytoskeleton, allowing simultaneous trials of cell mechanics including large deformation fireplace screens of the cell.
According to Prof. Gefen so far were performed fireplace screens using the algorithm two experiments: compression flattening of the cells and the cells stretch elastic surface. "We investigated fireplace screens the intensity fireplace screens and pressure distribution in the cells, especially the tension of the cell membrane and the surface of the nucleus, which may affect the permeability of these structures and thus interfere with the metabolism fireplace screens of the cell. The technique we have developed will allow to enrich considerably the trials examiners mechanics of cells mainly experiments classics examined at the load cell in the case of cell compression, stretching,, fireplace screens negative stress response (vacuum), punching, fireplace screens moving it, passing through the cell forces and hydrostatic fireplace screens pressure. this by giving the intensity values and load distribution fireplace screens on cell-specific or specific type of cells. "
Gefen believes that the method developed can become a generic method for the Study of external influences on cells not only in research but laboratory mentioned in a variety of fields, and it can lead to, among other things eliminating the need for at least some of the experiments on animals. Research work of Prof. Gefen and doctoral student under the guidance, Ms. Slumka, published this week in the journal's Leading biomechanics, Journal of Biomechanics.
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